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For instance, the administration of glucagon receptor antagonists increased hepatic fat content and plasma concentrations of LDL-cholesterol in people with type 2 diabetes [51]

The drug will still likely have the intestinal side effects common to GLP-1 drugs, but those symptoms may be more manageable with less frequent treatments

The TRIUMPH-Outcomes trial, beyond efficacy on clinical outcomes, will provide data on whether the drugs are safe, including in those with more advanced CKD (54)

Microbiome Repair Simple Comparison Table Supporting the microbiome may provide a more sustainable way to improve how GLP-1 signaling functions over time

In theory, the transfer to human milk of GLP-1 agonists may be low, as they are large peptide molecules (4751) ( Supplement 3 )