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The highest caution is usually needed in patients who already have moderate to severe retinopathy , diabetic macular edema, or recent unstable retinal disease

There was no glycemic rescue therapy in this study

It depends on how the medication is titrated, monitored, and individualized by providers who treat PCOS specifically, not just obesity

In the phase 2a trial with aleniglipron, 67% of patients had a reduction in weight by at least 6%, and 33% had a weight loss of more than 10% compared to 0% for placebo after 12 weeks

MarettyLGillDSimonsenLSohKZagkosLGalanakisMet alProteomic changes upon treatment with semaglutide in individuals with obesity