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Moylan S, Berk M, Dean OM, Samuni Y, Williams LJ, ONeil A, et al

Translationally, the apelinAPJ system illustrates a broader challenge for metabolic peptides with cardiovascular overlap: indication-specific development is likely required

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Glutathione participates in phase II detoxification by GST-mediated conjugation of electrophiles such as drugs, heavy metals, and lipid peroxides forming mercapturates that are eliminated via MRP/ABCC transporters

The GIP receptor activation adds metabolic effects that pure GLP-1 agonists do not provide, including potential benefits for bone formation and gut motility that may actually buffer against certain gastrointestinal side effects