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"It shows this drug develops some sort of therapeutic resistance that makes it not as effective anymore." RELATED | How GLP1 drugs work on body and brain against obesity Doctors say weight loss from GLP-1 medications typically includes a mix of 40 percent muscle and 60 percent fat
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Nat Chem Biol 3: 331-338
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The mechanism of action of GLP-1 RAs includes enhancing glucose-dependent insulin secretion, suppressing glucagon release, reducing appetite, and slowing gastric emptying through vagally mediated pathways [3, 4]
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