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Researchers studying this effect should note that caloric restriction itself produces fatigue independent of any pharmacological mechanism

Recent research conducted by [16] suggests a significant association between higher ergothioneine levels and reduced mortality, as well as a lower risk of cardiovascular disease

To avoid demand characteristics, we did not provide information about GLP-1 costs in the study manipulations, so our hypotheses relied on participants existing knowledge of GLP-1s

Larger, long-term trials are needed to define their optimal use in routine care

Special Considerations for Different Surgery Types Abdominal and gastrointestinal surgeries (hernia repair, appendectomy, gastric procedures) carry the highest interaction risk with GLP-1 medications, so longer medication stops (72+ hours) are common