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Some findings showed that serum Se concentration was inversely correlated with disease stage (P=0.011), and low levels of serum Se were potentially associated with high stage of thyroid cancer (80)

Following administration in animal models: BPC-157 demonstrates rapid systemic distribution within 15-30 minutes of administration TB-500 shows tissue-specific accumulation with preferential uptake in injured areas GHK-Cu exhibits copper-mediated transport and tissue binding characteristics Combined formulation provides both immediate and sustained bioactivity Distribution studies suggest that while each peptide follows distinct pathways, injury sites tend to concentrate all three components, potentially enhancing local therapeutic effects through multiple mechanisms

KEGG enrichment analysis further revealed that these genes were broadly involved in inflammation- and immune-related pathways, including the IL-17 signaling pathway and FoxO signaling pathway ( Figure 3D )

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