Compound 22 , a hybrid with the N-terminal from 21 and the C-terminal from 16 demonstrated a further enhanced potency (Ki = 23 nM) and a high selectivity for IRAP over AP-N ( 16 , devoid of a macrocyclic ring system in the N-terminal is not selective and inhibits both IRAP and AP-N activity, suggesting that introduction of proper conformational constrains in the N-terminal by macrocyclization improves selectivity ( 15 and Ang IV seem to adopt a -turn at the C-terminal when binding to IRAP, while in the case of 21 , a less well-defined turn conformation is adopted at the N-terminal
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Exploratory investigations of peptideprotein interactions in cell and tissue systems
This configuration provides gastroenterology, immunology, and molecular biology laboratories with a resilient, highly bioavailable vehicle to map localized cytokine suppression, cellular junction restoration, and non-competitive neuro-immune receptor cross-talk
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