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Early Human Development

Ex vivo duodenal segments from Fabp5 / mice secrete significantly less GIP in response to oleic acid with 4 v/v% bile in media than tissues isolated from wild-type mice (Shibue et al., 2015)

therefore, it must be transported into the cells by SLC7A11 (xCT) in exchange for glutamate, which implies that SLC7A11-mediated GSH biosynthesis largely relies on glutamine metabolism 55

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For example, PEG-lipid modified exenatide-loaded nanoparticles have been studied for their ability to cross mucosal barriers and improve oral bioavailability [34]