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Inhibition of the phosphorylation of Lyn, Syk kinase, and PLC-, which are essential for activation, and inhibition of ERK and JNK activation was also observed [135]

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In an orthotopic glioblastoma rat model, suppressing Ras-related protein Rab-27a expression inhibited the secretion of glioblastoma-derived exosomes, reduced lipid accumulation in infiltrating DCs within the brain, and decreased lipid peroxidation levels in mature DCs, thereby suppressing glioblastoma growth [82]