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Tirzepatide versus semaglutide In the direct head-to-head comparison, the 1-year risk of the primary endpoint including all-cause mortality was 1.3% (95% CI 1.2% to 1.5%) for tirzepatide and 1.3% (95% CI 1.2% to 1.5%) for semaglutide, resulting in a risk difference of 0.0% (95% CI 0.2% to 0.2%) and an HR of 1.06 (95% CI 0.95 to 1.18) (Fig

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By delaying stomach emptying, semaglutides prolong the feeling of fullness after eating, which helps control portion sizes and reduce overall calorie intake