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For example, HMGB1 enhances the immunosuppressive function of regulatory T cells (Tregs) via a RAGE-mediated mechanism and limits the number and activity of other T cells, which may influence immune responsiveness in chronic inflammatory conditions [56]

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All reagents were obtained from Sigma-Aldrich unless otherwise indicated

The reduced form has antioxidant properties which keep cells safe from being harmed by free radical molecules

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