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It is worthy to note that cardiovascular disease and kidney disease are closely interrelated [80] and diminished renal function is strongly associated with morbidity and mortality in heart failure patients [81]

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Instead, it stems from subcortical and autonomic mechanisms that hit adults aged 65 and older and patients with Type 2 diabetes particularly hard, highlighting an urgent need for proactive clinical supervision and medication de-escalation

Muscle tissue is metabolically active and contributes to heat generation