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Abstract Background Trace elements dyshomeostasis affects the physiological processes, metabolism, and immune function and leads to systemic and localised pathologies such as diabetes, cancer, and ocular degenerative diseases

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TRPV ion channels have been shown to play a role in sensitization and pain hypersensitivity in CDLBP

International Journal of Oncology, 2001

Injection into sensitive or low-fat tissue: Areas such as the abdomen, inner thigh, or other sites with minimal subcutaneous fat have less tissue cushioning and a higher density of sensory nerve endings, making pH-related discomfort more noticeable