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#NephJC Chat Tuesday June, 11th, 2024 at 9 pm Eastern (AEST = June 12th, 11am) Wednesday June 12th, 2024, at 9 pm Indian Standard by Time and 3:30 pm GMT (AEST = June 13th, 2am) N Engl J Med 2024 May 24

The ability of Arg 20 of Ex4(9-39) to form intra-helical interactions with Glu 16 and Glu 17 , and also for Lys 27 to interact intra-helically with Glu 24 , results in stabilization of the -helix (Figure 3B)

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2023;229(2):166.e1-166.e16

Simultaneously the compound reduces the elevated glucagon secretion by inhibiting alpha cells of the pancreas, as glucagon is known to be inappropriately elevated in diabetic patients