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The metanalysis includes 5,323 patients (56-61 years) with T2D inadequately controlled (HbA 1c 7-10.5%), baseline BMI 23-45 kg/m 2 , mean diabetes duration of 9-12 years, and randomized to receive a GLP-1RA or GIP/GLP-1RA versus placebo in add on to basal insulin for at least 24 weeks (24-40 weeks)

Conflicts of interest J.A

doi: 10.1016/j.arr.2007.08.007 138 MeiH.ChengN

Routine follow-ups were scheduled every three months to collect measurement data, to record blood pressure and medication usage, and to study outcome events including CVD, cancer, and all-cause mortality

Weeks 1 To 4 : 0.25 mg once weekly This is the starter dose