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doi:10.1016/j.jaad.2016.04.051

The melanin synthesis pathway is a key component of immunity, responsible for cytotoxic defense (Nappi and Ottaviani 2000) as well as the formation of an impermeable melanin barrier between healthy host tissue and an invading organism (Nappi 1973)

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[Confidence: Medium] Organ-Specific Targeting: By isolating the hippocampus, the researchers confirmed that GHK-Cu can cross the blood-brain barrier (or bypass it via olfactory tracts) to modulate neuroinflammation and synaptic plasticity, which are critical bottlenecks in age-related cognitive decline