In line with alterations of the small intestinal microbiota mediating nutrient-induced gutbrain signaling, direct small intestinal infusion of Lactobacillus gasseri restores intestinal lipid sensing 49,130
5E), which ranged from amino acids and nucleotides to energy metabolites and co-factors (Fig
The studies identified the following effects relating to the therapeutic effects of GLP-1 RAs in PCOS animal models: metabolic effects (reduced body weight, improved insulin sensitivity, decreased HOMA-IR, and improved glucose tolerance), hormonal regulation (decreased testosterone, LH/FSH ratio, and increased SHBG) and ovarian effects (reduced cystic follicles, increased corpus luteum formation, and restored regular estrous cycles)
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