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[Abstract]2022 Dec;148(12):3257-3266

A 2025 systematic review and meta-analysis in eClinicalMedicine (Tzang et al., 18 RCTs, 3,771 participants) found that adults with obesity who stopped GLP-1 receptor agonists regained an average of 5.63 kg, with HbA1c rising 0.25 percentage points and waist circumference, BMI, systolic blood pressure, and fasting glucose all deteriorating