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Medicare Part B offering a premium reimbursement for domestically sourced medicines and inputs could have broader impact, with commercial payers and insurers using Medicare as a benchmark in determining reimbursement standards

Future trials should be structured to assess whether initiating treatment in high-risk, cognitively unimpaired individuals (e.g., those with type 2 diabetes mellitus, obesity, and/or specific genetic risk factors such as APOE4) can delay or prevent cognitive decline onset

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