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Conversely, in another study, 615 patients with IGF-1 values in the lower half of the normal range were closely observed during 4.5 years

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Serine and glycine also charge the folate pool with one-carbon units, including N 10 -formyl-THF, that are ultimately used to produce nucleotides, methionine, and S-adenosylmethionine, the latter of which is the major methyl donor for methyltransferase reactions including those of DNA and histones [62, 63]