This peptide may contribute to tissue healing by helping regulate the expression of genes involved in inflammation, oxidative stress, and immune response
However, after irradiation, GPx1-KO and wild-type mice exhibited almost similar levels of intestinal GPx activity, and this was due to the radiation-induced compensatory upregulation of GPx2 in GPx1-KO mice
Wesolowska 2011
While further large-scale, controlled studies are warranted, the results of the Keto-CARE trial support the potential role of KDs as adjunctive therapies for improving metabolic parameters and enhancing treatment resilience in patients with metastatic cancer
While some ROS generation, produced via NADPH-dependent NOX and iNOS, is advantageous and necessary for pathogen clearance, it must be carefully titrated by antioxidant GSH which is itself regulated by NADPH-dependent glutathione reductase