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Disorders of creatine synthesis, characterized by brain creatinine deficiency, can lead to numerous deleterious symptoms including mental retardation, hypotonia, autism or behavioral problems, and seizures

Protocols run in one to three month cycles, and results in sleep and recovery are often the first changes patients notice

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Given the central role of the RAAS in hypertension, RAAS inhibitors, particularly angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs), are integral to antihypertensive therapy