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The induced Tregs are predominantly the IL-10 + cytotoxic-T-lymphocyte-associated antigen-4 (CTLA4) high Helios-subset with potent immunosuppressive activity, and they can migrate to extraintestinal organs to suppress systemic inflammation

Possible side effects particularly with a known allergy to plants of the daisy family (Asteraceae): Bloating and abdominal pain Diarrhoea Stomach cramps and nausea Headaches (rare) These symptoms typically resolve quickly after discontinuing milk thistle and leave no lasting effects

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