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Second, contrary to CVOTs on GLP-1 RAs that included T2DM patients with established cardiovascular disease or at high cardiovascular risk, tirzepatide trials randomized T2DM patients irrespective of presence of prior cardiovascular disease or cardiovascular risk factors, a fact that may account for the very low number of recorded MACE, and possibly for type II errors

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Tirzepatide seems to be the better option. The best weight loss results, according to the meta analysis, were with the highest doses of tirzepatide

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Epigenetic transgenerational actions of environmental factors in disease etiology