Chronic stress and anxiety have been linked to lower glutathione levels, likely because the biochemical stress response generates free radicals that consume glutathione
Glutathione Benefits, Healthline, Health Benefits of Glutathione, WebMD, Bernard Schmitt, Morgane Vicenzi, Catherine Garrel, Frdric M
NRF2 may reduce neuronal dopaminergic oxidative stress by providing NADPH for the activity of another NRF2 target, NQO1, which maintains dopamine in the hydroquinone conformation, a less reactive intermediate in dopamine metabolism (Zafar et al
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Methods Animal preparation The animal care and experimental protocols conformed to the recommendations in the 8th Edition of the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health (NIH, revised 2011) and were in accordance with the Animal Management Rules of China (Documentation 55, 2001, Ministry of Health, China)