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Overweight (body mass index equal to or greater than 27) with at least one weight-related problem such as high cholesterol, hypertension, or type 2 diabetes

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However, it is likely that the targeting of multiple risk factors through multiple domains acts on various mechanisms and pathways, such as vascular pathways, inflammatory-immune mediated responses, insulin signaling, and mechanisms related to biological aging, both in isolation and synergistically (Barbera et al., 2023

No systematic surveillance of adverse events