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Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, et al

ERK, Extracellular signal-regulated kinase 1/2

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distinct redox potentials across compartments (more reducing in mitochondria and cytosol, more oxidized extracellularly) set local signaling thresholds and oxidation states for protein thiols

Those are two completely different contexts, patients, and purposes one has nothing to do with the other, and the chemo dose is not something to replicate for cosmetic reasons