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Simvastatin inhibited the expression of HMGCR, and thus down-regulated the mevalonate pathway and GPX4 expression, thereby inducing ferroptosis in MDA-MB-231 cells (66)

Figure 4: Reduction in body weight from baseline level in treatment groups administered treatment with cagrilintide, semaglutide, or a combined treatment of both peptides

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QIAGEN) was used as a positive control for transfection efficiency in all experiments