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Since cystine did not significantly increase glutathione and inflammation was not reduced the results suggest that the protective mechanism of cystine supplementation is not related to mucosal glutathione levels

We think they work, we'd like to think they work, but obviously we need more information

According to the current state of studies, it seems that glutathione (GSH) is unlikely to be able to cross the blood-brain barrier intact, but that amino acids reach the brain cells.

J Control Release 321:122 Andary J, El Ballouz H, Abou-Khalil R (2025) Lebanese medicinal plants with ophthalmic properties

Following IP administration, drugs are absorbed into the mesenteric vessels, which drain into the portal vein and pass through the liver