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GLP-1 drugs have ushered in a new era in weight loss

GLP-1 activation primarily causes nausea and appetite suppression, while GIP signaling contributes to energy metabolism changes

This condition is implicated in various chronic diseases, including cardiovascular disorders, cancer, neurodegenerative diseases, autoimmune conditions, and diabetes mellitus

Although recent comprehensive functional genomics work has shed light on how OCTN2 missense variants affect both carnitine transport and membrane localisation 11 , the mechanism of carnitine transport and how clinically relevant variants affect transport at a molecular level are yet to be determined

Thyroid concerns: Animal studies identified thyroid C-cell tumours with some GLP-1 receptor agonists