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Given their large molecular size (34 kDa), GLP-1 RAs are unlikely to cross the placenta via passive diffusion

Common CVS Caremark Denial Reasons for Wegovy "Does not meet criteria" BMI or comorbidity requirements not documented "Step therapy not completed" Some plans require trying lifestyle changes first "Insufficient documentation" Missing weight history or comorbidity records "Employer plan exclusion" Some employers exclude weight loss medications entirely What to Do: Get the Denial in Writing Request a written denial letter with the specific reason for denial

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8 Based on data from the MAESTRO-NASH trial, resmetirom demonstrated histological benefits with a number needed to treat of five for the resolution of MASH and 8.5 for fibrosis regression, 9 thus posing significant economic challenges