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Women with PCOS exhibit elevated serum and follicular fluid levels of citrullinated histone H3 (citH3) and neutrophil elastase compared with age- and BMI-matched controls, correlating with insulin resistance, hyperandrogenism, and systemic inflammation [5]

2.2.4 Nuclear oxidative stress and TAO The nucleus, housing genetic material and regulatory molecules, is vulnerable to oxidative stress-induced damage (69)

Expression of the short-chain fatty acid receptor, GPR43, in the human colon

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ESR1 / ESR2 receptor sensitivity to estrogens that less-cleared reactive metabolites extend at tissue level