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Jama 2005;293(2):217-28 [PubMed: 15644549] 22

VPA poisoning is responsible for central nervous system manifestations ranging from ataxia, sedation and lethargy to coma, respiratory depression, seizures and intracranial hypertension [3]

The slower erosion curve for biologics (20-30% biosimilar market share after two years, versus 80-90% for small molecules) means that even after formal loss of exclusivity, the price compression that Cost Plus needs to add a drug to its formulary at a meaningful patient savings may not materialize for three to four years post-LOE

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Learn more about HMR's Medication Plan and see if you're eligible