It is often preferred due to its high selectivity and reduced side effects
An emerging mechanism of ferroptosis-like cell death points to cysteine loss as a key trigger, with one study demonstrating that erastin-induced cysteine deprivation triggered an alternative ferroptosis-like death pathway distinct from GPX4 inhibition, and that cysteine levels themselvesnot just glutathione levelswere the primary determinant of cellular fate
With this in mind, toxicity of copper excess in mammalian cells is explained by obstructing the control of the interactome of copper-sulfur containing redoxomes [166,167,168,169]
Delivery of insulin directly to the CNS is possible through intranasal devices, which, in early trials, has been shown to improve cognition compared to placebo in AD patients [159]
10.3389/fnins.2019.00831 Front Neurosci