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Conventional oncology strategies face challenges like non-specific toxicity, drug resistance, incomplete tumor eradication, high costs, and significant side effects that impact quality of life
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As noted above, multiple AAs were reduced in PBH, potentially contributing to reduced formation of intermediates such as pyruvate (alanine), acetyl-CoA (tryptophan, tyrosine, leucine, isoleucine, and phenylalanine), and succinyl-CoA (methionine, valine, and threonine)
Additional studies will be required to determine whether metformin can increase incretin receptor expression in human beta cells and thereby bolster incretin action in a meaningful way
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