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I think GLP-1s, and what we really know about them, is still kind of in its infancy, said Dr

Immunohistochemical Characterization of Monocytes-Macrophages and Dendritic Cells Involved in the Initiation of the Insulitis and Beta-Cell Destruction in NOD Mice

Collagen remodeling takes time (a fibroblast doesn't build new collagen overnight), so this is the window where visible skin firmness, texture, and hair density improvements become most noticeable

1984 Feb;63(2):335-41

This is the dose used in clinical settings and has been shown to effectively increase IGF-1 levels without significant suppression of endogenous growth hormone