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Ironsulfur (FeS) cluster Small inorganic protein cofactors consisting of iron and sulfide that occur in many biological systems, often as components of electron transfer proteins

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GLP-1 faces toward TM5 to form cation-pi stacking and hydrogen bond with the rotated down side-chain of R299 ECL2 , while that of W306 5.36b and R310 5.40b switch out from the receptor core to accommodate the approaching of histidine

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Getting this wrong can easily derail an entire study