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Hence, this autoantibody presence especially targets the autonomic and central nervous systems (503), which may explain the dysautonomia and immune dysregulation present in ME/CFS ( In other autoimmune diseases, natural antibodies are found against adrenergic, muscarinergic, and other G protein coupled receptors (GPCR) (512)

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Nonselective beta-blockers (such as propranolol) can cause bronchospasm in susceptible individuals, while cardioselective agents generally carry lower risk

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