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Under these conditions, we measured a decrease in insulin secretion in response to exendin-4 versus vehicle conditions, primarily due to elevated basal secretion levels at 11 mM glucose (Figure 1E, F), confirming that increased cholesterol levels reduce the GLP-1R glucoregulatory potential by decreasing its capacity to potentiate islet insulin secretion

Additionally, the use of Melanotan II may affect appetite suppression, which has sparked exploration of its potential for weight management

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