Mixing creatine with whey protein is generally safe for most people
Specific disease populations warranting focused investigation include sarcopenic obesity in older adults, HIV-associated lipodystrophy and wasting, recovery from major surgery or critical illness, and potentially select forms of growth hormone deficiency where preservation of endogenous secretory capacity is desirable
Back Mentlein, R, Galllwitz, B, Schmidt, WE (June 1993) 'Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36) amide, peptide histidine methionine and is responsible for their degradation in human serum', European Journal of Biochemistry , 214, 829-35
Discussion In the largest longitudinal study of MRS in pediatric concussion to date (545 participants in total, with over 200 participants at each timepoint in the study), we found that metabolites did not significantly change over time in the 6 months following concussion, nor were there differences between concussion or OI metabolite trajectories
The 8-week active phase accommodates meaningful metabolic adaptation while the 4-week break prevents potential tolerance development