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Changes in weight and metabolism may inadvertently affect hormone levels, potentially leading to fluctuations that could impact the stability of HRT regimens

doi: 10.3389/fimmu.2022.772446 27 RichardsPParkerHEAdriaenssensAEHodgsonJMCorkSCTrappSet al

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A study of 6522 patients found that 24 (0.4%) had experienced adverse reactions, the most frequent being anorexia, nausea, vomiting, and rash [29]