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A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport (42)

10.1158/1078-0432.CCR-21-2972 138 MickleM

Blood 95:510518 Mirandola P, Gobbi G, Ponti C, Sponzilli I, Cocco L, Vitale M (2006) PKCepsilon controls protection against TRAIL in erythroid progenitors

It contains antioxidants that may help remove toxins and free radicals, potentially contributing to a healthier appearance

Individual sgRNA scores of SLC25A40 and TXNRD2 from the CRISPR screens in indicated cell lines from Fig