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Exendin-4 versus human GLP-1 analogue structural pharmacology The clustering of immune-mediated adverse pulmonary eventsanaphylaxis, angioedema, bronchospasm, eosinophilic pneumoniapredominantly with exendin-4-based agents (exenatide, lixisenatide) rather than human GLP-1 analogues (liraglutide, semaglutide, dulaglutide) is neither coincidental nor mechanistically obscure

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