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Long-chain fatty acids must be conjugated to carnitine by carnitine palmitoyltransferase I (CPT-I) to form acylcarnitine, transported across the inner mitochondrial membrane by carnitine-acylcarnitine translocase (CACT), and released by CPT-II for beta-oxidation

Nature 596 , 211220 (2021)

Fernndez-Novoa, R

The SURMOUNT trials evaluating tirzepatide showed similar outcomes: discontinuation led to significant weight rebound despite ongoing diet and exercise efforts