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It also summarizes recent advances in drug discovery, including natural compounds, synthetic activators, and NAD + precursors, and evaluates their translational potential for MASLD therapy

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Valproic acid enhances CAR-T cell recognition of tumor targets and cytotoxic effects by upregulating the expression of NKG2D ligands (ULBP1-3) on tumor cell surfaces and activating the NKG2D-NKG2DL immune recognition axis (71)

Research shows that most patients regain 50-75% of lost weight within one year of discontinuation, primarily because appetite hormones like ghrelin rebound to baseline levels