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DPP-IV inhibitors and GLP-1 receptor agonists are mainly used to treat poorly controlled T2DM after sulfonylureas or thiazolidinediones have been employed

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While the specific length of treatment depends on your plan with your doctor, it appears that GLP-1s should be used longterm to maintain weight loss

When RNA therapeutics are applied in the brain, they are usually delivered to the CNS through intrathecal injections, ensuring adequate drug levels in disease-relevant areas by circumventing the BBB (Holm et al., 2022)