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In addition, it altered the resorption markers, RANKL (receptor activator NF-kB), tartrate resistant acid phosphatase (TRAcP5b) and cathepsin K activity

The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPAR

Moreover, through receptor-independent actions, CBD and CBG activate Nrf2, a transcription factor that upregulates antioxidant defenses such as SOD, CAT, and GSH-Px

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