After one month of treatment, patients may add the Precision Peptide Genetic Test ($99) to identify which GLP-1 receptor and metabolic pathway variations may influence their response to therapy, enabling truly personalized dosing strategies
Providers should also review all concurrent medications, as certain drugs (including some antidepressants, antipsychotics, and corticosteroids) can increase appetite and sugar cravings, potentially counteracting GLP-1 effects
However, they also noted that historic literature often suffers from methodological limitations, such as small sample sizes (averaging ~36 participants) and short study durations
The HDC gene is located on chromosome 15q21.2 and is composed of 14 exons that generate two alternatively spliced mRNAs encoding two distinct isoforms of the enzyme
NICE NG246 (Obesity: identification, assessment and management) recommends a structured programme combining dietary changes, increased physical activity, and behavioural support as the foundation of weight management, with pharmacological treatment considered as an adjunct rather than a standalone solution
