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The protection appears to result from the peptide's ability to bypass inhibitory IGFBP interactions, allowing more effective activation of IGF-1 signaling pathways that enhance sarcolemmal stability and reduce membrane damage during eccentric contractions

60 2,3-dioxygenase-1 (IDO1) is located in the critical branch of kynurenine metabolism and is activated by inflammatory factors such as TNF- and IL-6

Comp Biochem Physiol 155B:442448 Cazenava J, MdlA B, Pesce SF, Wunderlin DA (2006) Differential detoxification and antioxidant response in diverse organs of Corydoras paleatus experimentally exposed to microcystin-LR

Importantly, this anti-inflammatory action does not suppress immune function entirely like corticosteroids often do

Its documented effect is on visceral adipose tissue, the deep abdominal fat wrapped around organs, which is the same fat that increases cardiovascular and metabolic risk