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Funding This work was supported by the National Natural Science Foundation of China [81970023], the Shanghai Top-Priority Clinical Key Disciplines Construction Project [2017ZZ02013], the Shanghai Municipal Key Clinical Specialty [shslczdzk02201], and the Youth Fund of Zhongshan Hospital [2021-015]

This careful balancing act is crucial to avoid disrupting physiological homeostasis through excessive activation or incurring severe toxicity from off-target inhibition

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